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ASH offers four package options, where you can choose between scientific and educational content, purchase both at a lower price, or purchase the complete meeting including oral abstracts. Did you miss ASH 2019?
Median relapse-free survival (RFS) also was prolonged with CC-486 (10.2 months vs. 4.8 months; HR=0.65; 95% CI 0.52-0.81; p=0.0001).“While several agents have been studied and shown to increase relapse-free duration [in AML], demonstration of a survival benefit has been elusive,” Dr. Wei concluded.
Additionally, post relapse IHC findings were available for 18 patients who responded to axi-cel. The ZUMA-11 trial is currently enrolling participants to explore axi-cel with utomilumab, a 4-1BB inhibitor (NCT03704298). Presented at: 61st American Society of Hematology (ASH) Annual Meeting and Exposition; December 7-10, 2019; Orlando, FL. The study evaluated 108 patients, consisting of 101 from the phase II portion of the trial and 7 from the phase I group. Please see the sections below for information on how abstracts are reviewed, programmed, and published. An interactive search is available for the most recent years. Abstract 343. Randomization occurred within 4 months of patients achieving CR/CRi. Decisions are sent in mid-August. <<< View more from 2019 ASH Annual Meeting. Participants also had intermediate- or poor-risk cytogenetics, had an Eastern Cooperative Oncology Group (ECOG) performance status score of ≤3, and were not considered candidates for hematopoietic cell transplantation (HCT).After a median follow-up of 41.2 months, the median exposures to CC-486 and placebo were 12 cycles (range = 1-80) and 6 cycles (range = 1-73), respectively.Patients were randomized to receive either once-daily CC-486 300 mg (n=238) or placebo (n=234), administered on days 1-14 of 28-day cycles. These events included:Compared with placebo, treatment with CC-486 was associated with significantly longer overall survival (OS): 24.7 months versus 14.8 months, respectively (hazard ratio [HR] = 0.69; 95% CI 0.55-0.86; p=0.0009). If you would like to view the practice-changing abstracts from ASH 2019 and the expert opinions from our Steering Committee, please download the resource belowPractice-changing abstracts in multiple myeloma presented at ASH 2019The Multiple Myeloma Hub are pleased to present a series of expert interviews from the 61st American Society of Hematology (ASH)...Starting July 2019, the Multiple Myeloma (MM) Hub will be featuring articles...Smoldering multiple myeloma (SMM): an introduction to this month’s educational theme on the multiple myeloma (MM) HubThe Multiple Myeloma Hub are pleased to present a series of expert interviews from the 61st American Society of Hematology (ASH) meeting in Orlando, US.
Presented at the 2019 ASH Annual Meeting, December 7, 2019; Orlando, FL. According to research presented as a late-breaking abstract at the 2019 ASH Annual Meeting, treatment with CC-486, an oral formulation of the hypomethylating agent azacitidine, improved overall survival (OS) and relapse-free survival (RFS) when used as maintenance therapy in patients with acute myeloid leukemia (AML) who were in remission after induction chemotherapy.These benefits were seen across prespecified subgroups, Dr. Wei reported, including those with MRD, poor cytogenetic-risk disease, or ≥65 years. Abstract 203. bit.ly/2OXlwGr. According to research presented as a late-breaking abstract at the 2019 ASH Annual Meeting, treatment with CC-486, an oral formulation of the hypomethylating agent azacitidine, improved overall survival (OS) and relapse-free survival (RFS) when used as maintenance therapy in patients with acute myeloid leukemia (AML) who were in remission after induction chemotherapy.